Detection of HER2 Gene Polymorphism in Breast Cancer: PCR Optimization Study
نویسندگان
چکیده
منابع مشابه
Detection of HER2 Gene Polymorphism in Breast Cancer: PCR Optimization Study
Cancers are the most deadly diseases in the world and their incidences continue to increase over time. Particularly, breast cancer in females places 1(st) rank among other types of cancers in term of cancer cases (23%) and death incidence (14%). Recent findings support the correlation between (Ile)655(Val) SNP in the HER2 gene with breast cancer risk. Moreover, the (Ile)655(Val) HER2 gene polym...
متن کاملthe study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region
چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
15 صفحه اولAnalysis of HER2 gene amplification using Differential PCR in breast cancer patients of Isfahan Province
Background: Amplification of HER2 is seen in 20-30% of breast cancer cases. Measurement of HER2 gene amplification appears to be of vital importance in planning the treatment schedule for patients with breast carcinoma. The aim of our study was to evaluate HER2 amplification status in malignant and benign breast tumors by differential PCR (dPCR). Materials and Methods: The genomic DNA was ex...
متن کاملOptimization of Real Time PCR for Precise Measurement of HER2 Overexpression in Breast Cancer Specimens
Background: Breast cancer is one of the most prevalent malignancies among women in various countries. HER2 overexpression, which is due to different reasons, occurs in 20-30% of breast cancers. HER2 gene encodes an 185kDa transmembrane glycoprotein with 1255 amino acids. This active product triggers downstream intracellular signaling pathways inducing cell proliferation and cell survival. These...
متن کاملDetection of single Nucleotide Polymorphism E326K of SHBG Gene in Breast Cancer of Iranian Females
Background & Objective: Sex Hormone-Binding Globulin (SHBG) is a plasma glycoprotein that regulates the action of steroid hormones on several levels. Since SHBG is one of the growth regulators of breast cancer cells, the aim of this study was to evaluate the association between polymorphisms E326K and the risk of breast cancer. Materials & Methods: This study was done as a case-control study on...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientia Pharmaceutica
سال: 2016
ISSN: 0036-8709,2218-0532
DOI: 10.3797/scipharm.isp.2015.03